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Vermilion Parish is part of the six-parish Acadiana region of Louisiana, located in the south-central portion of the state. A mere 20 miles from Lafayette and 150 miles from New Orleans, the parish is easily accessible from Interstate 10 via LA Highways 26 and 13, U.S. Highway 90 and Interstate 49. For those traveling from Texas, the parish is accessible from LA Highway 82. Additionally, LA Highway 14 runs through the parish, offering a local route, as well as a direct link to U.S. 90, LA 26 and LA 13.

Abbeville Chris Crusta Memorial Airport is readily available in the parish, while Acadiana Regional Airport, a leading general aviation facility, is located within minutes in New Iberia. Corporate aviation, air cargo operations and commercial services are available at the Lafayette Regional Airport, which offers daily non-stop flights to destinations in Atlanta, Dallas/Fort Worth, Houston, Denver and Memphis. Travelers can also take advantage of Amtrak commuter rail service in nearby Lafayette. The station, located at 100 Lee Ave., is served by the Sunset Limited route, which runs between New Orleans and Los Angeles, California, and makes more than 20 stops in between.

Businesses utilize several rail lines that traverse the landscape of the parish, including the Acadiana Railway Company, Burlington Northern Sante Fe Railway, LA & Delta Railroad and Union Pacific Railroad. Plus, its location on the Gulf of Mexico provides convenient options for water travel through the Port of Vermilion in Abbeville, the Twin Parish Port in Delcambre and the nearby Port of Iberia in New Iberia.

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